Award & Press Release
- 2026.02.19
Self-assembly of a large metal-peptide capsid nanostructure through geometric control
A significant advancement in molecular engineering has produced a large, hollow spherical shell nanostructure through the self-assembly of peptides and metal ions, report researchers from Japan. This dodecahedral link structure, measuring 6.3 nanometers in diameter, was achieved by combining geometric principles derived from knot theory and graph theory with peptide engineering. The resulting structure demonstrates remarkable stability while featuring a large inner cavity suitable for encapsulating macromolecules, opening pathways for producing complex artificial virus capsids.
Reference
| ●Authors | ： | Yuuki Inomata, Sota Oguma, Nao Sagara, Ami Nishijima, Yuta Saburomaru, Satoshi Yoshida, Takashi Kajitani, Koya Shimokawa, Sota Sato, Michito Yoshizawa, Makoto Fujita,*, and Tomohisa Sawada,* |
| ●Title | ： | An M60L60 metal-peptide capsid with a 60-crossing woven network |
| ●Journal | ： | Chem |
| ●First published | ： | May 1, 2025 |
| ●ＤＯＩ | ： | 10.1016/j.chempr.2025.102555 |
Related information
- ■Science Tokyo News：Self-assembly of a large metal-peptide capsid nanostructure through geometric control
- ■Yoshizawa-Sawada Group
- ■Dept. of Chemical Science and Engineering, School of Materials and Chemical Technology
■The Fujita Laboratory, The University of Tokyo
■Institute for Molecular Science (IMS)
■Ochanomizu University
■Japan Science and Technology Agency (JST)
